Screwing the controller to the frame will not actually ground the system though. The negative line is not common to the chassis of the controller, it is internally isolated.
AussieJester, sounds like you had other issues that caused your problem. Even with the controller bolted to the bike frame, (at least with all controllers I have seen), you could touch the 5v throttle power feed to the case and all that would do is raise the case voltage to 5volts. There is no way that can somehow put 75 volt through controller,Since it is electrically insulated from the PCB inside it would not zap anything on the board.
Even if you had a battery voltage indicator wire to the throttle, so had the 75volt line as well, and flashed that too the case there would be no issue for the same reason.
The controller case can be at full battery voltage and will still work fine. My mate, Mark, had this on an Electric Rider Xlyte controller. There was physical damage to the insulating mounting strip that insulates the positive side FETS to the heatsink bar. This caused the whole controller case to be at full battery voltage. Bike ran perfectly like this for weeks, he had the controller wedged between fibre board in the battery box. Working on bike one day, while connected to battery he managed to touch a negative lead to the case of the controller, a spark and small flash and controller died.
He called me to look, I soon found case was live. Opened case, no short between PCB traces and case. Opened it up...heatsink bar was live. Removing FETS showed a hole and piece of swarf inderneath a positive FET. Been there since new.