If you mean weight on the rear wheel for a rear hubmotor, it's not really the weight that would be the problem (though this sometimes is too, for poorly built OEM hubmotor wheels), but the extra force from the middrive on a rear motor cover via the cassette or freewheel, especially when shifted to the smallest rear gear. It can cause the center of the cover to break away from the rest of the cover and leave you unable to ride at all, as the motor would now be unable to spin without gouging magnets on the stator laminations, and thus the wheel unable to spin. (if it's a geared hub instead of DD it could probably still spin but now it's not the cover bearing on that side is not carrying the load, but rather parts like gears that are not intended to).