Yes i am familiar with the Bolt, but it's not a production bike so you don't want/need to go copying their specs. They are catering to the opposite type of person than you, a builder. I also maintain that a 100+lb vehicle should not be running 48v. Especially if it's pushing 300A, that's just a bad ratio on all accounts.
well where to start...
I think you need to start doing a bit more research and come up with some sort of budget for each major component (controller, charger, batteries, BMS, motor etc) as well as very specific goals for output power continuous, peak, voltage, mid drive vs hub motor, and battery pack size (how much space do you have?). For each individual topic you can get lots of help on here or research what is already posted, but if you are asking about an entire system then it's hard to give you a specific build list without making lots of assumptions about cost, power, etc.
Going 50mph will require a little north of 5kW output power (unless i stand corrected), so you want to pick a motor that is rated a little bit more than that continuous.
At 48v, going 50mph that would be around 100A continuous draw, but again i would look at doing a 72/96V system to lower your amp draw, wire guage etc, there are lots of benefits, you just have to build a bigger battery pack.
The Midi-E Adaptto would be well suited to this, but it's always nice to have a little higher power capability (Max-E) in case you get better batteries, motor etc. http://adaptto.com/Products/Controllers/
It all depends on the budget and overall goal, if you just want to make an electric moped and don't mind it going regular moped speeds, then targeting 5kW continuous output capability might be fine. Without some method of shifting (which i would not recommend), you will not have very much off the line torque if your top speed is 50mph and you don't have a very high peak output. I personally think 5kW is pretty boring, especially if you have decent forks and brakes on the bike. I built an 8kW output moped (made from a Batavus) a few years back and it was kinda cool but it did get old, now i'm more than doubling the output on my new build.